TorsinA Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB66712-50, MB66712-100

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Swiss-Prot: O14656

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/4000)

Background: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of TorsinA protein.

Bioworld Molecular Weight: ~ 35 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TorsinA expression in ZR751 (A) whole cell lysates., ???, ???, ???

DQ2; DYT1; TORA; Torsin-1A; Dystonia 1 protein; Torsin ATPase 1; Torsin family 1 member A

Immunogen: Recombinant fusion protein of human TorsinA. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified