Recombinant Human PSMA Protein (His Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSH033667-10, PKSH033667-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: PSMA

Target Symptom: Glutamate carboxypeptidase 2; FGCP; GCPII; mGCP; NAALADase I; PSMA; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; FOLH1; GCP2; FGCP; GCPII; Mgcp; NAALADase I; FOLH; mGCP; NAALAD1; NAALAdase; PSM; PSMA

Research Area: Signal Transduction; Cancer; metabolism;

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: N-His

UNIProt ID: Q04609

Accession: Q04609

Background: Glutamate carboxypeptidase 2, also known as FOLH1, PSMA, belongs to the M28B subfamily and the peptidase M28 family. It is highly expressed in prostate epithelium and can be detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimer disease and Huntington disease. It has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. PSMA involves in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, PSMA cleaves Gly-Pro-AMC. PSMA is stable at pH greater than 6.5.

Sequence: Lys44-Ala750

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mMMES, 150mMNacl, 5% Trehalose, pH5.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 80.6 kDa

Observed MW: 110 kDa

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Research Use Only