PRMT5 IN-1, a hemiaminal, is a covalent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions.

Product information

CAS Number: 2366149-83-7

Molecular Weight: 418.83

Formula: C19H19ClN4O5

Chemical Name: (2R,3S,4R,5R)-2-[(R)-(4-chlorophenyl)(hydroxy)methyl]-5-{5-hydroxy-3,6,8,10-tetraazatricyclo[7.3.0.0²,⁶]dodeca-1(9),2,7,11-tetraen-10-yl}oxolane-3,4-diol

Smiles: O[C@H]1[C@@H](O[C@@H]([C@H]1O)[C@H](O)C1C=CC(Cl)=CC=1)N1C=CC2=C1N=CN1C(O)CN=C12

InChiKey: LTPABOINPMWTKU-BHUSIORFSA-N

InChi: InChI=1S/C19H19ClN4O5/c20-10-3-1-9(2-4-10)13(26)16-14(27)15(28)19(29-16)23-6-5-11-17-21-7-12(25)24(17)8-22-18(11)23/h1-6,8,12-16,19,25-28H,7H2/t12?,13-,14+,15-,16-,19-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.