Lamin A/C (R386) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS1446-50, BS1446-100

Sizes: 50µl, 100µl

Swiss-Prot: P02545

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

Background: A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Lamin A/C (R386) polyclonal antibody detects endogenous levels of Lamin A/C protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Lamin A/C (R386) polyclonal antibody at 1:500 dilution
Lane 1: HepG2 whole cell lysate (40ug)
Lane 2: L02 whole cell lysate (40ug)
Lane 3: PC12 whole cell lysate (40ug)
Lane 4: AML-12 whole cell lysate (40ug)
Lane 5: A549 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Lamin A/C (R386) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 74, 65 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C

Immunogen: Synthetic peptide, corresponding to amino acids 351-400 of Human Lamin A/C.

Conjugate: Unconjugated

Modification: Unmodified