Creatine Kinase B Monoclonal Antibody

Catalogue Numbers: MB66873-50, MB66873-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P12277

Host: Mouse

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens .Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa . Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation .During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Creatine Kinase B protein.

Extra Notes: Western blot analysis of Creatine Kinase B expression in MDAMB453 (A), 293 (B), Y79 (C), mouse stomach (D), mouse brain (E) whole cell lysates.

Bioworld Molecular Weight: ~ 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: CKBB; Creatine kinase B-type; B-CK; Creatine kinase B chain

Immunogen: Recombinant fusion protein of human Creatine Kinase B. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified