Plectin Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91090-50, BS91090-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15149(Human) Q9QXS1(Mouse) P30427(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IP,

All Applications: WB:1:1,000
IHC:1:100-1:500

Background: Plectin is an abundant cytoskeletal protein that is involved in cytoplasm stabilization. Plectin has been shown to crosslink intermediate filaments to microtubules and microfilaments, and to anchor intermediate filaments to the plasma and nuclear membranes. Plectin binds both Lamin B and vimentin, and this binding is regulated by a variety of protein kinases. Phosphorylation by PKA or PKC results in decreased binding to Lamin B, and phosphorylation by PKA enhances the plectin-vimentin interactions. Plectin is also a substrate for p34cdc2 kinase. Several alternative splice isoforms of plectin are known to exist. Mutations in human plectin are known to cause epidermolysis bullosa simplex with muscular dystrophy (EBS-MD).

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Plectin polyclonal antibody detects endogenous levels of Plectin protein.

Bioworld Molecular Weight: 531 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of paraffin-embedded rat skeletal muscle tissue using anti-Plectin antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-Plectin antibody. Counter stained with hematoxylin.

Alternative Name: PCN, PLTN, HD1, PLEC, EBS1, EBSO, HD1, Hemidesmosomal protein 1, PCN, pleC, PLEC, PLEC1, PLEC1b, Plectin 1, Plectin 1 intermediate filament binding protein 500kDa, Plectin 6, Plectin, Plectin-1, PLTN,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified