Notch4 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11841-50, MB11841-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q99466

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of NOTCH4 in Hela, U87-MGLysates using Notch4 antibody.

Bioworld Molecular Weight: Calculated MW: 210 kDa; Observed MW: 36 kDa

Specificity: IgG

Alternative Name: NOTCH4; INT3; Neurogenic locus notch homolog protein 4; Notch 4; hNotch4

Immunogen: A synthetic peptide of human NOTCH4

Conjugate: Unconjugated

Modification: Unmodified