PF-06733804 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

Product information

CAS Number: 1873373-33-1

Molecular Weight: 474.38

Formula: C20H19F5N4O4

Chemical Name: 6-amino-5-{[(3S)-4,4-difluoro-1-{2-[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-N-methylpyridine-3-carboxamide

Smiles: CNC(=O)C1=CC(O[C@H]2CN(CC2(F)F)C(=O)CC2=CC=C(C=C2)OC(F)(F)F)=C(N)N=C1

InChiKey: FTAFQADCGCSJAH-HNNXBMFYSA-N

InChi: InChI=1S/C20H19F5N4O4/c1-27-18(31)12-7-14(17(26)28-8-12)32-15-9-29(10-19(15,21)22)16(30)6-11-2-4-13(5-3-11)33-20(23,24)25/h2-5,7-8,15H,6,9-10H2,1H3,(H2,26,28)(H,27,31)/t15-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PF-06733804 (Compound 19) also inhibits hERG in the FP and PX assay with IC50s of 79 μM and 88 μM, respectively.

Products are for research use only. Not for human use.