AMPKβ2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20834-50, ES20834-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],

Alternate Name: PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2

Source: Rabbit

Applications: WB

Dilution: WB: 1:1000-2000

Reactivity: Human; Mouse; Rat

Immunogen: Recombinant Protein of AMPKβ2

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Observed Band (KD): 30kD

Human Gene ID: 5565

Human SWISS Prot NO: O43741

Subcellular Location: nucleoplasm, cytosol, nucleotide-activated protein kinase complex,

Research Use Only