Phospho-PKR (T446) Rabbit Monoclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Sizes: 50µl, 100µl

Catalogue Numbers: BS40095-50, BS40095-100

Swiss-Prot: P19525

Host: Rabbit

Phospho-PKR (T446) Rabbit Monoclonal Antibody-BS40095

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human

Applications: WB, IHC, IP, ChIP,

All Applications: WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50

Background: PKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis.

Purification and Purity: Affinity-chromatography

Specificity: Phospho-PKR (T446) Antibody detects endogenous levels of total Phospho-PKR (T446)

Bioworld Molecular Weight: 68kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of PKR phosphorylation expression in HeLa cell lysate treated with Calyculin A and TNF-alpha., Immunohistochemical analysis of paraffin-embedded human colon, using Phospho-PKR (T446) Antibody.

Alternative Name: E2AK2; E2AK2; EIF2AK1; EIF2AK2; MGC126524; PKR p68 kinase; PKR; PRKR;

Immunogen: A synthesized peptide derived from human Phospho-PKR (T446)

Modification: Phosphorylated

Conjugate: Unconjugated