Phylloflavan is an antileishmanial agent with an intracellular EC50 of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL).

Product information

CAS Number: 98570-83-3

Molecular Weight: 498.48

Formula: C26H26O10

Synonym:

Phylloflavan

Chemical Name: (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl (S)-5-(3,4-dihydroxyphenyl)-3-hydroxypentanoate

Smiles: O[C@@H](CCC1=CC=C(O)C(O)=C1)CC(=O)O[C@H]1CC2=C(C=C(O)C=C2O)O[C@@H]1C1=CC=C(O)C(O)=C1

InChiKey: FKDRTLFRRHQTGU-TYFWRAIDSA-N

InChi: InChI=1S/C26H26O10/c27-15(4-1-13-2-5-18(29)21(32)7-13)11-25(34)35-24-12-17-20(31)9-16(28)10-23(17)36-26(24)14-3-6-19(30)22(33)8-14/h2-3,5-10,15,24,26-33H,1,4,11-12H2/t15-,24-,26+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Aloufi BH, Snoussi M, Sulieman AME. Antiviral Efficacy of Selected Natural Phytochemicals against SARS-CoV-2 Spike Glycoprotein Using Structure-Based Drug Designing. Molecules. 2022 Apr 8;27(8):2401. doi: 10.3390/molecules27082401. PMID: 35458599; PMCID: PMC9025634.
2. Kolodziej H, Kayser O, Kiderlen AF, Ito H, Hatano T, Yoshida T, Foo LY. Proanthocyanidins and related compounds: antileishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-alpha-release in the murine macrophage-like cell line RAW 264.7. Biol Pharm Bull. 2001 Sep;24(9):1016-21. doi: 10.1248/bpb.24.1016. PMID: 11558561.

Products are for research use only. Not for human use.