MaxiKβ2 (I186) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS9144-50, BS9144-100

Sizes: 50µl, 100µl

Swiss-Prot: Q9Y691

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: MaxiKβ subunit 1 consists of two putative transmembrane domains, an extracellular loop containing three consensus sequences for N-linked glycosylation and four cysteine residues that might form disulfide bridges. MaxiKβ subunit 1, one of four subunits in the MaxiKβ family, is expressed predominately in smooth muscle tissue but is also found in brain, liver and lymphatic tissues. MaxiKβ subunit 1 associates with MaxiKα to form a calcium-activated potassium channel (also designated MaxiK and BK channel). MaxiKβ subunit 1 increases the sensitivity of the MaxiKα to calcium and voltage. The MaxiKα/β1 channel is the most sensitive of all Maxi channels to calcium. MaxiKβ plays an important role in vasoregulation by controlling the sensitivity of MaxiK channels to calcium, which leads to the proper amount of arterial relaxation.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MaxiKβ2 (I186) polyclonal antibody detects endogenous levels of MaxiKβ2 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of MaxiKβ2 (I186) pAb at 1:500 dilution
Lane 1: SK-OVCAR3 whole cell lysate (40ug)
Lane 2: A2780 whole cell lysate (40ug)
Lane 3: The Ovary tissue lysate of Rat (40ug)
Lane 4: The Brain tissue lysate of Mouse (40ug), Immunohistochemistry (IHC) analyzes of MaxiKβ2 (I186) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 27 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; BKbeta2; Hbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Calcium-activated potassium channel subunit beta; Charybdotoxin receptor subunit beta-2; k (VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2; Slo-beta2; KCNMB2; Calcium-activated potassium channel subunit β-2; BK channel subunit β-2; BKβ2; BKβ2; Hβ2; Calcium-activated potassium channel, subfamily M subunit β-2; Calcium-activated potassium channel subunit β2; Charybdotoxin receptor subunit β-2; k (VCA)β-2; Maxi K channel subunit β-2; Slo-β-2; Slo-β2;

Immunogen: Synthetic peptide, corresponding to amino acids 154-203 of Human MaxiKβ2.

Conjugate: Unconjugated

Modification: Unmodified