ATP-citrate synthase Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA10818-50, RA10818-100

Citations, Manuals and MSDS Available upon request.

Background: ATP citrate lyase (ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],

Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Storage Instructions: -20°C/1 year

Applications: WB; IF/ICC; FCM

Species Cross-Reactivity: Human; Mouse; Rat; Bovine; Chicken; Pig; sheep

GeneID (Human): 47

SWISS: P53396

Source: Mouse

Research Use Only