N-(Azido-PEG3)-N-bis(PEG3-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2055042-56-1

Molecular Weight: 738.91

Formula: C34H66N4O13

Chemical Name: 1,25-di-tert-butyl 13-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)-4,7,10,16,19,22-hexaoxa-13-azapentacosanedioate

Smiles: CC(C)(C)OC(=O)CCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCC(=O)OC(C)(C)C

InChiKey: GZZBWIKELRCXSD-UHFFFAOYSA-N

InChi: InChI=1S/C34H66N4O13/c1-33(2,3)50-31(39)7-13-41-19-25-47-28-22-44-16-10-38(12-18-46-24-30-49-27-21-43-15-9-36-37-35)11-17-45-23-29-48-26-20-42-14-8-32(40)51-34(4,5)6/h7-30H2,1-6H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.