NUP88 Polyclonal Antibody

Catalogue Numbers: BS5831-50, BS5831-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q99567

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup88 (nucleoporin 88kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis. The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NUP88 polyclonal antibody detects endogenous levels of NUP88 protein.

Extra Notes: Western blot (WB) analysis of NUP88 pAb at 1:500 dilution
Lane1:HCT116 whole cell lysate(40ug)
Lane2:HepG2 whole cell lysate(40ug)
Lane3:PC3 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 83kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88

Immunogen: Synthetic peptide, corresponding to amino acids 399-444 of Human NUP88.

Conjugate: Unconjugated

Modification: Unmodified