Inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC50 > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

Product information

CAS Number: 866396-34-1

Molecular Weight: 312.80

Formula: C14H21ClN4O2

Chemical Name: (2R,5S)-1-(2-{[1-(hydroxymethyl)cyclopentyl]amino}acetyl)pyrrolidine-2,5-dicarbonitrile hydrochloride

Smiles: Cl.N#C[C@@H]1CC[C@H](C#N)N1C(=O)CNC1(CO)CCCC1

InChiKey: RHCWAHDCHQTNBR-IWKKHLOMSA-N

InChi: InChI=1S/C14H20N4O2.ClH/c15-7-11-3-4-12(8-16)18(11)13(20)9-17-14(10-19)5-1-2-6-14;/h11-12,17,19H,1-6,9-10H2;1H/t11-,12+;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.