KOR-1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA26700-50, RA26700-100

Citations, Manuals and MSDS Available upon request.

Background: OPRK1 encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Alternative Names: OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1

Applications: IHC-p; IF (paraffin section) ; WB; ELISA

Species Cross-Reactivity: Mouse; Rat

Protein MW (KDa): 42

Source: Rabbit

Research Use Only