CD6 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7995-50, ES7995-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Alternate Name: CD6; T-cell differentiation antigen CD6; T12; TP120; CD antigen CD6

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human CD6. AA range:250-299

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 73kD

Human Gene ID: 923

Human SWISS Prot NO: P30203

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938).; [Soluble CD6]: Secreted. The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain.

Research Use Only