N,N'-bis-(propargyl-PEG4)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2107273-08-3

Molecular Weight: 819.46

Formula: C47H63ClN2O8

Chemical Name: 2-[(1E,3E)-5-[(2Z)-3,3-dimethyl-1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-2,3-dihydro-1H-indol-2-ylidene]penta-1,3-dien-1-yl]-3,3-dimethyl-1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-3H-indol-1-ium chloride

Smiles: [Cl-].CC1(C)C2=CC=CC=C2N(CCOCCOCCOCCOCC#C)/C/1=C\C=C\C=C\C1=[N+](CCOCCOCCOCCOCC#C)C2=CC=CC=C2C1(C)C

InChiKey: FJFLIVHAHJSGKV-UHFFFAOYSA-M

InChi: InChI=1S/C47H63N2O8.ClH/c1-7-24-50-28-32-54-36-38-56-34-30-52-26-22-48-42-18-14-12-16-40(42)46(3,4)44(48)20-10-9-11-21-45-47(5,6)41-17-13-15-19-43(41)49(45)23-27-53-31-35-57-39-37-55-33-29-51-25-8-2;/h1-2,9-21H,22-39H2,3-6H3;1H/q+1;/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.