High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM?for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an acute model of coronary ischemia-reperfusion injury. Orally active.

Product information

CAS Number: 344930-95-6

Molecular Weight: 556.63

Formula: C27H32N4O7S

Chemical Name: 6-methoxy-2-[({4-oxo-9-[2-(piperidin-1-yl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-2-yl}oxy)methyl]-4-(propan-2-yl)-2,3-dihydro-1λ⁶,2-benzothiazole-1,1,3-trione

Smiles: COC1C=C(C(C)C)C2=C(C=1)S(=O)(=O)N(COC1=CC(=O)N3C=CC=C(OCCN4CCCCC4)C3=N1)C2=O

InChiKey: DRZXDZYWZSKFDL-UHFFFAOYSA-N

InChi: InChI=1S/C27H32N4O7S/c1-18(2)20-14-19(36-3)15-22-25(20)27(33)31(39(22,34)35)17-38-23-16-24(32)30-11-7-8-21(26(30)28-23)37-13-12-29-9-5-4-6-10-29/h7-8,11,14-16,18H,4-6,9-10,12-13,17H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.