TXNIP Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91389-50, BS91389-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9H3M7(Human) Q8BG60(Mouse) Q5M7W1(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF, IHC, FC

All Applications: WB:1:1000-1:5,000
ICC/IF:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TXNIP polyclonal antibody detects endogenous levels of TXNIP protein.

Bioworld Molecular Weight: 44 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TXNIP on different lysates using anti-TXNIP antibody at 1/1,000 dilution.
Positive control: Lane 1: PC-12 Lane 2: Human skeletal muscle Lane 3: NIH-3T3 Lane 4: Hela, ICC staining TXNIP in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: TXNIP, VDUP1, EST01027, HHCPA78, THIF, Thioredoxin binding protein 2, Thioredoxin interacting protein, Thioredoxin-binding protein 2, Thioredoxin-interacting protein, TXNIP, TXNIP, Upregulated by 1, 25 dihydroxyvitamin D 3, VDUP1, Vitamin D3 up-regulated protein 1,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified