COA7 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-52496-60, E-AB-52496-120, E-AB-52496-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: COA7

Target Synonym: beta-lactamase hcp-like protein; C1orf163; Chromosome 1 open reading frame 163; FLJ12439; Hcp beta lactamase like protein C1orf163; Hypothetical protein LOC65260; RESA1; Sel1 repeat containing 1; sel1 repeat-containing protein 1

Research Areas: Cell Biology

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q96BR5

Background: The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. COA7 (cytochrome c oxidase assembly factor 7), also known as RESA1, SELRC1 or C1orf163, is a 231 amino acid mitochondrial protein that belongs to the hcp beta-lactamase family. Consisting of five Sel1-like repeats, COA7 may be associated with respiratory chain assembly. COA7 is encoded by a gene located on human chromosome 1p32.3. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3, 000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene, which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.

Concentration: 0.9 mg/mL

Immunogen: Full length fusion protein

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Calculated MW: 26 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only