PLGF Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91092-50, BS91092-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P49763(Human) P49764(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: IHC, FC

All Applications: IHC:1:50-1:200
FC:1:50-1:100

Background: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast growth factor (FGF), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). Like VEGF, several PlGF variants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PlGF signaling. While VEGF homodimers and VEGF/PlGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PlGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PlGF. VEGF and PlGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.

Purification and Purity: Protein affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PLGF polyclonal antibody detects endogenous levels of PLGF protein.

Bioworld Molecular Weight: 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PLGF antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-PLGF antibody. Counter stained with hematoxylin.

Alternative Name: PlGF, PGF, PGFL, D12S1900, Pgf, PGFL, PIGF, Placenta growth factor, Placental growth factor, Placental growth factor, vascular endothelial growth factor related protein, PlGF 2, PlGF, PLGF, PlGF2, SHGC 10760,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified