TIMP2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91348-50, BS91348-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P16035(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, FC

All Applications: WB:1:500-1:2,000
FC:1:10-1:50

Background: TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases 1, 2, 3 and 4) complex with metalloproteinases such as collagenases, gelatin-ases and stromelysins, resulting in irreversible inactivation of the metallopro-teinase. TIMP-1 has been found to be identical to EPA (erythroid-potentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus and remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart, with low levels expressed in liver, brain, lung, thymus and spleen.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TIMP2 polyclonal antibody detects endogenous levels of TIMP2 protein.

Bioworld Molecular Weight: 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TIMP2 on K562 cells lysates using anti-TIMP2 antibody at 1/500 dilution., Flow cytometric analysis of Hela cells with TIMP2 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.

Alternative Name: TIMP-2, TIMP2, CSC 21K, CSC-21K, CSC21K, Metalloproteinase inhibitor 2, Metalloproteinase inhibitor 2 precursor, TIMP 2, TIMP metallopeptidase inhibitor 2, TIMP-2, TIMP2, TIMP2, Tissue Inhibitor of Metalloproteinase 2, Tissue inhibitor of metalloproteinases 2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified