PEPC rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20649-50, ES20649-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009],

Alternate Name: PGC; Gastricsin; Pepsinogen C

Source: Rabbit

Applications: WB

Dilution: WB: 1:2000-5000

Reactivity: Plants

Immunogen: Synthetic Peptide of PEPC

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Observed Band (KD): 105-109kD

Subcellular Location: extracellular space, extracellular exosome,

Research Use Only