GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 µM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 µM, but only weakly affected PKA.

Product information

CAS Number: 2444764-03-6

Molecular Weight: 269.73

Formula: C15H12ClN3

Chemical Name: N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)aniline

Smiles: ClC1C=CC(=CC=1)NC1=CC(=CC=C1)C1=CNN=C1

InChiKey: GPXJDHFWTOJHQQ-UHFFFAOYSA-N

InChi: InChI=1S/C15H12ClN3/c16-13-4-6-14(7-5-13)19-15-3-1-2-11(8-15)12-9-17-18-10-12/h1-10,19H,(H,17,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 200 mg/mL (741.48 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GKI-1 inhibits full-length human GWL, and shows cellular efficacy.

Products are for research use only. Not for human use.