Recombinant Human TNFSF7/CD70 Protein (Fc Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSH032209-10, PKSH032209-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: TNFSF7; CD70

Target Synonym: CD70 antigen; CD70; CD27 ligand; Tumor necrosis factor ligand superfamily member 7; CD27LG; TNFSF7; CD27L

UNIProt ID: P32970

Research Areas: Cancer; immunology; Stem cells

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-Fc

Accession: P32970

Background: CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Sequence: Gln45-Pro193

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 43.6 kDa

Observed MW: 52 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only