6-fluoro-DL-Tryptophan is a serotonin (5-HT) synthesis inhibitor. Serotonin or 5-hydroxytryptamine (5-HT), a monoamine neurotransmitter, is biochemically derived from tryptophan. Serotonin is primarily present in the gastrointestinal tract, blood platelets, and the central nervous system of animals. Serotonin is considered to be a contributor to feelings of well-being and happiness. In vitro: The potential competition was investigated between L-tryptophan (TRP) and 6-fluoro-DL-tryptophan (6-F-TRP). In equilibrium dialysis experiments, albumin bound about 80% of TRP and 50% of 6-F-TRP. Competitive inhibition was assessed as the decrease in the apparent Ka of TRP in the presence of 6-F-TRP, with no modification of the N value . In vivo: Rats werer administered 6-fluoro-DL-tryptophan (6F-Trp) and its neurochemical effects on central catechole and indole were evaluated. Results showed that neither norepinephrine nor dopamine and its major metabolites were affected by 6F-Trp. With regard to serotonin (5-HT), 6F-Trp could induce a transient depletion in all the studied brain areas, with a maximum of about 60-65% obtained between 1 and 3 hr. After 6 hr, 5-HT levels returned to control values. In addition, the 5-hydroxyindolacetic acid (5-HIAA) level was also reduced 3 hr after 6F-Trp administration. A large dose-dependent increase in tryptophan was seen in the four brain areas, mainly due to an inhibition of tryptophan incorporation into protein, as demonstrated by experiments with mouse neuroblastoma cells . Clinical trial: So far, no clinical study has been conducted.

Product information

CAS Number: 7730-20-3

Molecular Weight: 222.22

Formula: C11H11FN2O2

Chemical Name: 2-amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid

Smiles: NC(CC1=CNC2C=C(F)C=CC=21)C(O)=O

InChiKey: YMEXGEAJNZRQEH-UHFFFAOYSA-N

InChi: InChI=1S/C11H11FN2O2/c12-7-1-2-8-6(3-9(13)11(15)16)5-14-10(8)4-7/h1-2,4-5,9,14H,3,13H2,(H,15,16)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.