SMARCC1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91257-50, BS91257-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q92922(Human) D3ZJU5(Rat)

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, ICC IF FC IP,

All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
FC:1:50-1:100
IP:1:10-1:50

Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SMARCC1 polyclonal antibody detects endogenous levels of SMARCC1 protein.

Bioworld Molecular Weight: 123 kDa (Predicted band size) 150 kDa (Observed band size)

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SMARCC1 on different cell lysates using anti-SMARCC1 at 1/500 dilution.
Positive control:
Line 1: Mouse thymus tissue
Line 2: HL-60, ICC staining SMARCC1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: BAF155, SMARCC1, AI115498, BAF 155, BAF155, BRG 1 associated factor 155, BRG1 associated factor 155, BRG1-associated factor 155, Chromatin remodeling complex BAF155 subunit, CRACC 1, CRACC1, Mammalian chromatin remodeling complex BRG 1 associated factor 155, Mammalian chromatin remodeling complex BRG1 associated factor 155, Rsc 8, Rsc8, SMARC C1, SMARCC 1, SMARCC1, SMRC1, SRG 3, SRG3, SWI 3, SWI/SNF complex 155 kDa subunit, SWI/SNF complex subunit SMARCC1, SWI/SNF related matrix associated actin dependent regulator of chromatin c1, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1, SWI3,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified