PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro.

Product information

CAS Number: 72596-74-8

Molecular Weight: 217.29

Formula: C11H11N3S

Chemical Name: 9-thia-3,7-diazatricyclo[8.4.0.0²,⁷]tetradeca-1(14),2,10,12-tetraen-8-imine

Smiles: N=C1SC2=CC=CC=C2C2=NCCCN21

InChiKey: JNENSSREQFBZGT-UHFFFAOYSA-N

InChi: InChI=1S/C11H11N3S/c12-11-14-7-3-6-13-10(14)8-4-1-2-5-9(8)15-11/h1-2,4-5,12H,3,6-7H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (230.11 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs. PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity. PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM. PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora.

Products are for research use only. Not for human use.