TRx0237 (Leucomethylene blue) Mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. TRx0237 (Leucomethylene blue) Mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes.

Product information

CAS Number: 1236208-20-0

Molecular Weight: 477.62

Formula: C18H27N3O6S3

Chemical Name: N3,N3,N7,N7-tetramethyl-10H-phenothiazine-3,7-diamine; bis(methanesulfonic acid)

Smiles: CN(C)C1=CC2SC3=CC(=CC=C3NC=2C=C1)N(C)C.CS(O)(=O)=O.CS(O)(=O)=O

InChiKey: SPCMQFLNOVTUBM-UHFFFAOYSA-N

InChi: InChI=1S/C16H19N3S.2CH4O3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;2*1-5(2,3)4/h5-10,17H,1-4H3;2*1H3,(H,2,3,4)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 110 mg/mL (230.31 mM; Need ultrasonic). H2O : 12.5 mg/mL (26.17 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

TRx0237 (Leucomethylene blue, 100 nM, 48 h) Mesylate not only decreases the tau and p-tau expression levels, but also reversed the promoting effects of Aβ25-35 on orexin A and adenosine A1R expression levels.

Products are for research use only. Not for human use.