TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 of 99 nM in a cell-based assay. TrkA-IN-1 has analgesic activity.

Product information

CAS Number: 1680179-43-4

Molecular Weight: 392.45

Formula: C25H20N4O

Chemical Name: 3-(9H-fluoren-9-yl)-1-(2-methyl-4-phenylpyrimidin-5-yl)urea

Smiles: CC1=NC(=C(C=N1)NC(=O)NC1C2=CC=CC=C2C2=CC=CC=C21)C1C=CC=CC=1

InChiKey: PKOROKYRNIDSPX-UHFFFAOYSA-N

InChi: InChI=1S/C25H20N4O/c1-16-26-15-22(23(27-16)17-9-3-2-4-10-17)28-25(30)29-24-20-13-7-5-11-18(20)19-12-6-8-14-21(19)24/h2-15,24H,1H3,(H2,28,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 8.33 mg/mL (21.23 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.