XAB2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-53550-60, E-AB-53550-120, E-AB-53550-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: XAB2

Target Synonym: 0610041O14Rik; adapter protein ATH 55; Adapter protein ATH-55; Ath55; AV025587; Crn related protein kim1 ; crn-related protein kim1; DKFZp762C1015; HCNP; HCNP protein; HCRN; KIAA1177; NTC90; PP3898; Pre-mRNA-splicing factor SYF1; Protein HCNP; RNA splicing factor; SYF1; SYF1 homolog; SYF1 homolog; RNA splicing factor ; SYF1 pre mRNA splicing factor; SYF1; Xab2; XPA binding protein 2; XPA-binding protein 2

Research Areas: Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9HCS7

Background: HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.

Concentration: 0.4 mg/mL

Immunogen: Synthetic peptide of human XAB2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Calculated MW: 100 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only