Actinin-α2 Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA10726-50, RA10726-100

Citations, Manuals and MSDS Available upon request.

Background: actinin alpha 2 (ACTN2) Homo sapiens Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013],

Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Storage Instructions: -20°C/1 year

Applications: WB; IF/ICC

Species Cross-Reactivity: Human; Rat; Bovine; Chicken; Dog; Pig; Zebrafish

GeneID (Human): 88

SWISS: P35609

Source: Mouse

Research Use Only