Tri-(PEG1-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1381861-95-5

Molecular Weight: 365.38

Formula: C15H27NO9

Chemical Name: 3-(2-{bis[2-(2-carboxyethoxy)ethyl]amino}ethoxy)propanoic acid

Smiles: OC(=O)CCOCCN(CCOCCC(O)=O)CCOCCC(O)=O

InChiKey: QNHMUDRSUKYNFE-UHFFFAOYSA-N

InChi: InChI=1S/C15H27NO9/c17-13(18)1-7-23-10-4-16(5-11-24-8-2-14(19)20)6-12-25-9-3-15(21)22/h1-12H2,(H,17,18)(H,19,20)(H,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.