Parvalbumin alpha Polyclonal Antibody

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Catalogue Numbers: BS67762-50, BS67762-100

Sizes: 50µl, 100µl

Swiss-Prot: P20472

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: Parvalbumin (PV, PVALB) is a member of the EF-hand family of calcium-binding proteins, containing EF-hand domains with a high affinity for calcium and magnesium. Parvalbumin is expressed in both the soma and in processes of specific subclasses of GABAergic interneurons. Parvalbumin is a slow calcium buffer, meaning it accelerates the initial phase of decay of calcium after an action potential, which likely inhibits facilitation and is thought to regulate short-term synaptic plasticity. Altered function of PV positive interneurons has been implicated in many neurological diseases, such as Alzheimer’s disease, autism spectrum disorder, schizophrenia, and bipolar disorder.

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Parvalbumin alpha protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Parvalbumin alpha expression in mouse skeletal muscle (A), rat skeletal muscle (B) whole cell lysates., Immunohistochemical analysis of Parvalbumin alpha staining in human esophageal formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Bioworld Molecular Weight: ~ 14 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Parvalbumin alpha

Immunogen: Recombinant protein corresponding to human Parvalbumin alpha. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified