Endothelin B Receptor rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20766-50, ES20766-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016],

Alternate Name: Endothelin B receptor (ET-B; ET-BR; Endothelin receptor non-selective type)

Source: Rabbit

Applications: IHC; IF

Dilution: IHC 1:100-200

Reactivity: Human; Rat; Mouse

Immunogen: Synthetic Peptide of Endothelin B Receptor AA range: 270-350

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 50kD

Human Gene ID: 1910

Human SWISS Prot NO: P24530

Subcellular Location: Cell membrane; Multi-pass membrane protein. internalized after activation by endothelins.

Research Use Only