Inhibin β-A Polyclonal Antibody

Catalogue Numbers: BS60379-50, BS60379-100

Sizes: 50µl, 100µl

Alternative Name: Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein; EDF; INHBA; Inhibin Βa; Inhibinβ A; Inhibinβ-A

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P08476

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The TGFβ superfamily is composed of numerous growth and differentiation factors, including transforming growth factor β (TGFβ) 1, 2 and 3; growth/differentiation factor (GDF) 1 through 8; Mullerian inhibiting substance (MIS); bone morphogenic protein (BMP) 2 through 8; glial cell line-derived neurotrophic factor (GDNF); Inhibins (α, β-A, β-B and β-C), Lefty and Nodal. Members of the TGFβ superfamily are involved in embryonic development and adult tissue homeostasis. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins and activins are involved in regulating a number of functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, Insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins oppose the funtions of Inhibins. Inhibins are predominantly expressed in liver, uterus and ovary tissue. Inhibin A, a dimer of α and β-A, and Inhibin B, a dimer of α and β-B, have been shown to inhibit the secretion of follicle stimulating hormone. Inhibin β-C forms a homodimer and its expression is predominant in adult liver.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Inhibin β-A polyclonal antibody detects endogenous levels of Inhibin β-A protein.

Bioworld Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Inhibin β-A polyclonal antibody at 1:500 dilution
Lane 1: HEK293T cell lysate
Lane 2: sp2/0 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human Inhibin β-A.

Conjugate: Unconjugated

Modification: Unmodified