FITC Anti-Mouse CD122/IL-2RB Antibody [5H4]

Size: 100μg

Catalogue Number: E-AB-F1029UC-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD122/IL-2RB

Target Synonym: Interleukin-2 receptor subunit beta, Il2rb, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, CD122,

Conjugation: FITC

Host: Rat

Species Reactivity: Mouse

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10^6 cells in 100 μL volume].

Isotype: Rat IgG2a, κ

Clone No.: 5H4

UNIProt ID: P16297

Background: CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F09833C

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

GeneID: 16185

Storage: This product can be stored at 2-8°C for 12 months. Please protect from prolonged exposure to light and do not freeze.

Shipping: Ice bag