BAI-1 (Q732) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS2784-50, BS2784-100

Sizes: 50µl, 100µl

Swiss-Prot: O14514

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

Background: Brain-specific angiogenesis inhibitors, including BAI-1, BAI-2 and BAI-3, are integral membrane proteins belonging to the G protein-coupled receptor 2 family. In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines. BAI-1 protein is specifically expressed in the brain and found to localize to the cytoplasm and membrane in neuronal cells of the cerebral cortex. Reduced expression of BAI-1 in some glioblastoma cell lines and cancer tissues implicates the functional role of BAI-1 as an inhibitor of angiogenesis. The exact mechanisms underlying BAI-1 anti-angiogenetic activity are still being investigated. BAI-1 may be involved in mediating the p53 signal in suppression of glioblastoma, as well as in cell adhesion and signal transduction. Additional research shows an inverse correlation with vascularization and BAI-1 expression in both colorectal carcinomas and pulmonary adenocarcinomas.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: BAI-1 (Q732) polyclonal antibody detects endogenous levels of BAI-1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of BAI-1 (Q732) polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: PC12 whole cell lysate, Immunohistochemistry (IHC) analyzes of BAI-1 (Q732) pAb in paraffin-embedded human brain.tissue.

Bioworld Molecular Weight: ~ 174 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: BAI1; Brain-specific angiogenesis inhibitor 1

Immunogen: Synthetic peptide, corresponding to amino acids 711-760 of Human BAI-1.

Conjugate: Unconjugated

Modification: Unmodified