NR2C2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB66995-50, MB66995-100

Swiss-Prot: P49116

Host: Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2 . TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs) . TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation . TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation . High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2 . Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis .

Product: Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of NR2C2 protein.

Extra Notes: Western blot analysis of NR2C2 expression in PC3 (A), Jurkat (B), MoLT4 (C), F9 (D), NIH3T3 (E), PC12 (F), CHO (G) whole cell lysates.

Bioworld Molecular Weight: ~ 67 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: TAK1; TR4; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4

Immunogen: KLH-conjugated synthetic peptide of human NR2C2. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified