IC50: 4 and 20 μM for MMP-2 and MMP-9, respectively cis-ACCP is a type IV collagen-specific MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) belong to a family of proteases that play a keyrole in tissue remodeling and repair via degrading extracellular matrix proteins, therefore enabling cell migration. In vivo: Aninmal study showd that cis-ACCP could reduce metastasis formation in mice by approximately 90% when administered by a repetitive once daily dosing regimen at 50 mg/kg via oral or i.p. routes and was nontoxic up to 500 mg/kg, following i.p. administration daily for two weeks. In addition, the pharmacokinetic investigation in rats revealed distribution restricted into the extracellular fluid, the site of action for the antimetastatic activity and rapid elimination from blood . Clinical trial: So far, no clinical study has been conducted.

Product information

CAS Number: 777075-44-2

Molecular Weight: 222.18

Formula: C7H15N2O4P

Chemical Name: {[(1R,2S)-2-aminocyclohexyl]carbamoyl}phosphonic acid

Smiles: N[C@H]1CCCC[C@H]1NC(=O)P(O)(O)=O

InChiKey: XHCXISPZIHYKQD-NTSWFWBYSA-N

InChi: InChI=1S/C7H15N2O4P/c8-5-3-1-2-4-6(5)9-7(10)14(11,12)13/h5-6H,1-4,8H2,(H,9,10)(H2,11,12,13)/t5-,6+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.