Nesprin3 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11294-50, MB11294-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q6ZMZ3

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Nesprin3 in Jurkat, HelaLysates using Nesprin3 antibody.

Bioworld Molecular Weight: Calculated MW: 112 kDa; Observed MW: 112 kDa

Specificity: IgG

Alternative Name: KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341

Immunogen: Recombinant protein of human Nesprin3

Conjugate: Unconjugated

Modification: Unmodified