HOXC8 Polyclonal Antibody

Catalogue Numbers: BS60569-50, BS60569-100

Sizes: 50µl, 100µl

Alternative Name: Homeobox protein Hox-C8; Homeobox protein Hox-3A; HOXC8; HOX3A

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P31273

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: HoxC8 (Homeobox protein Hox-C8, Hox-3A) is a 242 amino acid protein encoded by the human gene HOXC8. HoxC8 belongs to the Antp homeobox family and contains one homeobox DNA-binding domain. The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Homeobox region 3 contains at least seven homeoboxes within 160 kb of DNA. Overexpression of the HOXC8 transgene causes cartilage defects, the severity of which depends upon transgene dosage. This abnormal cartilage is characterized by an accumulation of proliferating chondrocytes and reduced maturation. Since HoxC8 is normally expressed in chondrocytes, it may be responsible for skeletal development other than pattern formation in a tissue-specific manner, hypothetically by controlling the progression of cells along the chondrocyte differentiation pathway.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: HOXC8 polyclonal antibody detects endogenous levels of HOXC8 protein.

Bioworld Molecular Weight: ~ 28 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of HOXC8 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: PC12 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human HOXC8

Conjugate: Unconjugated

Modification: Unmodified