COL25A1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7762-50, ES7762-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

Alternate Name: COL25A1; Collagen alpha-1 (XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human Collagen XXV alpha1. AA range:101-150

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 64kD

Human Gene ID: 84570

Human SWISS Prot NO: Q9BXS0

Subcellular Location: Membrane; Single-pass type II membrane protein. After proteolytic cleavage, CLAC is secreted.

Research Use Only