p-iodo-Clonidine (hydrochloride) is a partial agonist of the alpha 2-adrenergic receptor . The adrenergic receptors are G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. There are two main groups of adrenergic receptors: α receptors and β receptors. α2-adrenergic receptor is a Gi coupled receptor, which causes a decrease in neurotransmitter release, as well as a decrease of cAMP activity resulting in smooth muscle contraction . p-iodo-Clonidine (hydrochloride) is a partial agonist of the alpha 2-adrenergic receptor. Clonidine is an antihypertensive α2-adrenergic receptor agonist. PIC had minimal agonist activity in inhibiting adenylate cyclase in platelet membranes through α2-adrenergic receptor, but it increased platelet aggregation induced by ADP with EC50 value of 1.5 μM. PIC also inhibited epinephrine-induced aggregation with IC50 value of 5.1 μM. PIC competed for [3H]bromoxidine binding with Ki value of 1.0 nM. PIC bound to the alpha 2B-AR in NG-10815 cell membranes with Kd value of 0.5 +/- 0.1 nM .

Product information

CAS Number: 108294-57-1

Molecular Weight: 392.45

Formula: C9H9Cl3IN3

Chemical Name: N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

Smiles: Cl.ClC1C=C(I)C=C(Cl)C=1NC1NCCN=1

InChiKey: ULCGXOSKNHMYAX-UHFFFAOYSA-N

InChi: InChI=1S/C9H8Cl2IN3.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2H2,(H2,13,14,15);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.