TGS1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-62562-60, E-AB-62562-120, E-AB-62562-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: TGS1

Target Synonym: TGS1; NCOA6IP; PIMT; PIPMT

Research Areas: Cancer,Epigenetics and Nuclear Signaling,Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q96RS0

Background: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7G caps of snRNAs and snoRNAs to a 2, 2, 7-trimethylguanosine (m(2, 2, 7G cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs. Plays a role in transcriptional regulation.

Concentration: 1 mg/mL

Immunogen: Recombinant fusion protein of human TGS1

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 96kDa

Observed MW: 97kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only