TH (phospho Ser62) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7384-50, ES7384-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008],

Alternate Name: TH; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Ser31. AA range:1-50

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 60kD

Human Gene ID: 7054

Human SWISS Prot NO: P07101

Subcellular Location: Cytoplasm, perinuclear region. Nucleus. Cell projection, axon. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals.

Research Use Only