AP 811 is a selective atrial natriuretic peptide clearance receptor (APN-CR, NPR3) antagonist (Ki=0.48 nM). AP 811 displays >20,000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation.

Product information

CAS Number: 124833-45-0

Molecular Weight: 915.09

Formula: C46H66N12O8

Chemical Name: (3S)-3-{[(1S)-4-[(diaminomethylidene)amino]-1-{[(2S)-2-methylbutyl]carbamoyl}butyl]carbamoyl}-3-[(2S,3S)-2-[(2S)-5-[(diaminomethylidene)amino]-2-{2-[4-(naphthalene-2-amido)phenyl]acetamido}pentanamido]-3-methylpentanamido]propanoic acid

Smiles: C[C@@H](CC)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CC1C=CC(=CC=1)NC(=O)C1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC[C@@H](C)CC

InChiKey: UNMJSSQZDQBGDS-OCFLPWLCSA-N

InChi: InChI=1S/C46H66N12O8/c1-5-27(3)26-53-41(63)34(13-9-21-51-45(47)48)56-43(65)36(25-38(60)61)57-44(66)39(28(4)6-2)58-42(64)35(14-10-22-52-46(49)50)55-37(59)23-29-15-19-33(20-16-29)54-40(62)32-18-17-30-11-7-8-12-31(30)24-32/h7-8,11-12,15-20,24,27-28,34-36,39H,5-6,9-10,13-14,21-23,25-26H2,1-4H3,(H,53,63)(H,54,62)(H,55,59)(H,56,65)(H,57,66)(H,58,64)(H,60,61)(H4,47,48,51)(H4,49,50,52)/t27-,28-,34-,35-,36-,39-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.