KDEL Receptor 3 (L95) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS3124-50, BS3124-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O43731

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC:1:50~1:200

Background: Soluble proteins in the endoplasmic reticulum (ER) contain a specific carboxy terminal sequence KDEL (Lys-Asp-Glu-Leu), and include the coat proteins required for vesicle budding from the ER, proteins that form retrogradevesicles on post-ER compartments, and integral membrane proteins that target vesicles to their correct destination. The retention of these soluble proteins in the ER depends on the interaction of the KDEL sequence with the corresponding KDEL receptor, also designated ERD2, in the Golgi apparatus.When KDEL proteins reach the Golgi complex, they are recognized by the KDEL receptor and transported retrograde in COPI-coated vesicles back to the ER. The small GTPase ADP-ribosylation factor 1 (ARF1), a regulator of vesicle transport, interacts with the KDEL receptor.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of KDEL Receptor 3 (L95) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 25 kDa

Specificity: KDEL Receptor 3 (L95) polyclonal antibody detects endogenous levels of KDEL Receptor 3 protein.

Alternative Name: ER lumen protein retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; Short name=KDEL receptor 3; KDELR3

Immunogen: Synthetic peptide, corresponding to amino acids 71-120 of Human KDEL Receptor 3.

Conjugate: Unconjugated

Modification: Unmodified